https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14944 Wed 11 Apr 2018 14:30:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50422 Tue 25 Jul 2023 18:19:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52539 Tue 17 Oct 2023 10:12:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48411 Thu 16 Mar 2023 14:04:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50641 HSD17B3 mutations have poorly masculinised external genitalia that can appear as ambiguous or female, whilst having internal Wolffian structures and testes. Recent studies in mice deficient in HSD17B3 have made the surprising finding that testosterone production is maintained, male mice are masculinised and remain fertile, suggesting differences between mice and human testosterone production exist. We discuss the phenotypic differences observed and the possible other pathways and enzymes that could be contributing to testosterone production and male development. The identification of alternative testosterone synthesising enzymes could inform the development of novel therapies to endogenously regulate testosterone production in individuals with testosterone deficiency.]]> Mon 31 Jul 2023 16:48:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44770 Mon 24 Oct 2022 09:03:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46185 Mon 14 Nov 2022 10:36:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52812 in vivo and validated which of these are likely to arise primarily from Sertoli cells based on relevant mouse testis RNASeq datasets. We used a different, but complementary, approach to identify Sertoli cell-enriched proteins in human TIF, taking advantage of high-quality human testis genomic, proteomic and immunohistochemical datasets. We identified a total of 47 and 40 Sertoli cell-enriched proteins in mouse and human TIF, respectively, including 15 proteins that are conserved in both species. Proteins with potential roles in angiogenesis, the regulation of Leydig cells or steroidogenesis, and immune cell regulation were identified. The data suggests that some of these proteins are secreted, but that Sertoli cells also deposit specific proteins into TIF via the release of extracellular vesicles. In conclusion, we have identified novel Sertoli cell-enriched proteins in TIF that are candidates for regulating somatic cell-cell communication and testis function.]]> Fri 27 Oct 2023 15:56:20 AEDT ]]>